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Twenty-five patients(23%)developed dementia.The prognosis regarding occurrence of dementia during the follow-up period,evaluated by the Kaplan-Meier method,was significantly worse in the subjects with the greatest evidence of cerebral atrophy 9p<0.009)and in subjects who underwent new cardiovascular episodes(p<0.000001).No differences were seen in the frequency of vascular risk factors or the site or volume of lesions between the demented and nondemented groups.Patients with lacunar infarcts suffer from dementia 4-12 times more frequently than the normal population.Cerebral;atrophy and recurrent stroke,as well as other as-yet unclarified factors,are involved in producing dementia. |
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